{"product_id":"cyanokit-hydroxocobalamin-5g-x-1","title":"Cyanokit (Hydroxocobalamin 5g) x 1","description":"\u003cdiv class=\"title\"\u003e\n\u003ch2 class=\"anchor\"\u003eCyanokit (Hydroxocobalamin 5g) x 1\u003c\/h2\u003e\n\u003ch3 class=\"anchor\" id=\"ISI\"\u003eINDICATION\u003c\/h3\u003e\nCYANOKIT is indicated for the treatment of known or suspected cyanide poisoning.\u003cbr\u003eImportant Safety Information and Indication\u003cbr\u003eWARNINGS AND PRECAUTIONS\u003c\/div\u003e\n\u003cdiv class=\"body\"\u003e\n\u003cp\u003e\u003cstrong\u003eEmergency Patient Management\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIn conjunction with CYANOKIT, treatment of cyanide poisoning must include immediate attention to airway patency, adequacy of oxygenation and hydration, cardiovascular support, and management of seizures. Consideration should be given to decontamination measures based on the route of exposure.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cstrong\u003eRisk of Anaphylaxis and Other Hypersensitivity Reactions\u003c\/strong\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003eConsider alternative therapies, if available, in patients with known anaphylactic reactions to hydroxocobalamin or cyanocobalamin.\u003c\/li\u003e\n\u003cli\u003eAllergic reactions may include: anaphylaxis, chest tightness, edema, urticaria, pruritus, dyspnea, and rash. Allergic reactions including angioneurotic edema have also been reported in postmarketing experience.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cstrong\u003eRisk of Renal Injury\u003c\/strong\u003e\n\u003cul\u003e\n\u003cli\u003eAcute renal failure with acute tubular necrosis, renal impairment and urine calcium oxalate crystals have been reported following CYANOKIT therapy. Monitor renal function for 7 days following CYANOKIT therapy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cstrong\u003eRisk of Increased Blood Pressure\u003c\/strong\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003eSubstantial increases in blood pressure may occur following CYANOKIT therapy. Monitor blood pressure during therapy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cstrong\u003eLaboratory Tests\u003c\/strong\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003eBecause of its deep red color, hydroxocobalamin has been found to interfere with colorimetric determination of certain laboratory parameters (e.g., clinical chemistry, hematology, coagulation, and urine parameters). Be aware of this when reporting and interpreting laboratory results.\u003c\/li\u003e\n\u003cli\u003eWhile determination of blood cyanide concentration is not required for management of cyanide poisoning and should not delay treatment with CYANOKIT, collecting a pretreatment blood sample may be useful for documenting cyanide poisoning as sampling post-CYANOKIT use may be inaccurate.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cstrong\u003eClinical Methods\u003c\/strong\u003e\u003cbr\u003e\n\u003cul\u003e\n\u003cli\u003eBecause of its deep red color, hydroxocobalamin may cause hemodialysis machines to shut down due to an erroneous detection of a \"blood leak\". This should be considered before hemodialysis is initiated in patients treated with hydroxocobalamin.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cstrong\u003ePhotosensitivity\u003c\/strong\u003e\n\u003cul\u003e\n\u003cli\u003eHydroxocobalamin absorbs visible light in the UV spectrum. It therefore has potential to cause photosensitivity. While it is not known if the skin redness predisposes to photosensitivity, patients should be advised to avoid direct sun while their skin remains discolored.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cstrong\u003ePregnancy and Lactation\u003c\/strong\u003e\n\u003cul\u003e\n\u003cli\u003eAvailable data from cases reported in the published literature and postmarketing surveillance with CYANOKIT use in pregnant women are insufficient to identify a drug-associated risk for major birth defects, miscarriage, or adverse maternal and fetal outcomes. There are risks to the pregnant woman and fetus associated with untreated cyanide poisoning. In animal studies, hydroxocobalamin administered to pregnant rats and rabbits during the period of organogenesis caused skeletal and soft tissue abnormalities, including alterations in the central nervous system, at exposures similar to human exposures at the therapeutic dose.\u003c\/li\u003e\n\u003cli\u003eBreastfeeding is not recommended during treatment with CYANOKIT.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cbr\u003e\u003cstrong\u003eADVERSE REACTIONS\u003c\/strong\u003e\n\u003cul\u003e\n\u003cli\u003eThe most common adverse reactions (\u0026gt;5%) include transient chromaturia, erythema, oxalate crystals in urine, rash, increased blood pressure, nausea, headache and infusion site reactions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e","brand":"Cyanokit","offers":[{"title":"Default Title","offer_id":53942142075244,"sku":"ITM01604","price":2860.3,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0012\/8440\/7394\/files\/cyanokit-hydroxocobalamin-5g-x-1-cyanokit-1245794595.png?v=1782231616","url":"https:\/\/checkout.medshop.com.au\/products\/cyanokit-hydroxocobalamin-5g-x-1","provider":"Medshop Australia","version":"1.0","type":"link"}